Prions and domains are two very different things, so I'm not sure what you are asking.
A prion is an infectious agent composed entirely of protein material, which can fold in abnormal ways and cause disease in the nervous system of humans and animals.
A domain, in the context of computer science and web development, refers to a subsection of the internet with a specific name and function, often used for a particular organization, business, or purpose.
If you could provide more context or clarify your question, I would be happy to try and help you.
